Supertraining

The below may be of interest to members:

J Appl Physiol (June 5, 2008). doi:10.1152/japplphysiol.00006.2008

EXERCISE BUT NOT DIET-INDUCED WEIGHT LOSS DECREASES SKELETAL MUSCLE
INFLAMMATORY GENE EXPRESSION IN FRAIL OBESE ELDERLY
Charles P Lambert1, Nicole R Wright2, Brian N Finck1, and Dennis T
Villareal1*

Many obese elderly persons have impaired physical function associated
with an increased chronic inflammatory response. We evaluated 12
weeks of exercise (aerobic and resistance) or 12 weeks of weight loss
(~7% reduction) on skeletal muscle mRNAs for toll-like receptor-4,
(TLR-4), mechanogrowth factor (MGF), tumor necrosis factor- (TNF-),
and interleukin-6 (IL-6) in 16 obese (BMI: 38±2 kg/m2) older (69±1
yrs) physically frail individuals. m. vastus lateralis biopsies were
obtained at 0 and 12 weeks and analyzed by real time RT-PCR. Body
composition was assessed by dual x-ray absorptiometry. Body weight
decreased (-7.5 ±1.2 kg, p=0.001) in the weight loss group, but not
in the exercise group (-0.3±0.8 kg, p=0.74). Fat free mass (FFM)
decreased (-2.9±0.6 kg, p=0.010) in the weight loss group and
increased (1.6±0.6 kg, p=0.03) in the exercise group. Exercise
resulted in a 37% decrease in TLR-4 mRNA (p<0.05) while weight loss
had no significant effect. Additionally, exercise led to a
significant (50%) decrease in IL-6 and TNF- mRNA (p<0.05) while
weight loss had no effect. Exercise increased MGF mRNA (~2 fold,
p<0.05) but weight loss had no effect.

In conclusion, exercise but
not weight loss had a beneficial effect on markers of muscle
inflammation and anabolism in frail obese elderly individuals.

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Jamie Carruthers
Wakefield, UK